5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Base Information

Chemical Name:5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine
CAS No.:492438-83-2
Molecular Formula:C₂₃H₂₂N₄O₄
Molecular Weight:418.452
Hs Code.:

Synonyms:5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

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Chemical Property of 5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

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Technology Process of 5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

There total 11 articles about 5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 492438-69-4
9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 492438-83-2
5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: N,N-dimethyl acetamide; With trichlorophosphate; In chloroform; at 20 ℃; for 0.416667h;

9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine; In chloroform; at 70 ℃; for 30h; Further stages.;
DOI:10.1021/jo026508x

Reference yield:

: 290332-96-6
ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate

: 492438-83-2
5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 67 percent / o-xylene / 0.42 h / 170 °C

2.1: 94 percent / sodium hydride / dimethylformamide / 12 h / 20 °C

3.1: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

4.1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

5.1: 85 percent / Na / ethanol / 72 h / -15 °C

6.1: 82 percent / CH₂Cl₂ / 24 h / 20 °C

7.1: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

8.1: 97 percent / tetrahydrofuran / 24 h / 50 °C

9.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

9.2: 90 percent / CHCl₃ / 30 h / 70 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium; silica gel; sodium hydride; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; o-xylene; N,N-dimethyl-formamide; 6.1: Staudinger reaction;
DOI:10.1021/jo026508x

Reference yield:

: 290333-00-5
[4-methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanol

: 492438-83-2
5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

2.1: 85 percent / Na / ethanol / 72 h / -15 °C

3.1: 82 percent / CH₂Cl₂ / 24 h / 20 °C

4.1: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

5.1: 97 percent / tetrahydrofuran / 24 h / 50 °C

6.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

6.2: 90 percent / CHCl₃ / 30 h / 70 °C

With manganese(IV) oxide; tetrabutyl ammonium fluoride; sodium; silica gel; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; 3.1: Staudinger reaction;
DOI:10.1021/jo026508x