1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione
• CAS No.: 1152256-93-3
• Molecular Formula: C₂₆H₂₃F₂NO₇
• Molecular Weight: 499.468

Synonyms:1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione

Chemical Property of 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione

Chemical Property:

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Technology Process of 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione

There total 1 articles about 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-deaza-1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]uracil (29910-54-1) → 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione (1152256-93-3)

Guidance literature:

With Selectfluor; In acetonitrile; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1021/jm900203h

Reference yield: 92.0%

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione (1152256-93-3) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-4-[(ethoxycarbonyl)methylene]-3,3-difluoro-3,4-dihydropyridin-2(1H)-one (1152257-16-3)

Guidance literature:

In dichloromethane; for 3.5h; Reflux;

DOI:10.1021/jm900203h

Reference yield: 75.0%

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoropyridine-2,4(1H,3H)-dione (1152256-93-3) → 1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3-fluoro-4-hydroxypyridin-2(1H)-one (1152257-24-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; for 24h; under 760.051 Torr;

DOI:10.1021/jm900203h

upstream raw materials:

3-deaza-1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]uracil

Downstream raw materials:

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3-fluoro-4-hydroxypyridin-2(1H)-one

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-3,3-difluoro-3,4-dihydro-4-hydroxy-4-methylpyridin-2(1H)-one

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-ribofuranosyl]-3,3-difluoro-3,4-dihydro-4-hydroxy-4-phenylpyridin-2(1H)-one

1-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-4-[(ethoxycarbonyl)methylene]-3,3-difluoro-3,4-dihydropyridin-2(1H)-one

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