N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
• CAS No.: 1401423-46-8
• Molecular Formula: C₁₃H₁₀ClF₃N₈
• Molecular Weight: 370.724

Synonyms:N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property of N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

There total 4 articles about N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile (1401423-45-7) → N2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1401423-46-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 125 ℃; for 18h;

Reference yield: 85.0%

3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile (1401423-45-7) → N2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1401423-46-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 125 ℃; for 18h;

DOI:10.1021/jm301020q

Reference yield:

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine (515824-43-8) → N2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1401423-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 100 °C / Sonication; Sealed tube; Inert atmosphere

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 125 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; ammonium chloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine

4-amino-3-chlorobenzonitrile

Downstream raw materials:

N₂-(2-chloro-4-(1-methyl-1H-tetrazol-5-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

N²-(2-chloro-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

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