3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile

Base Information

• Chemical Name: 3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile
• CAS No.: 1401423-45-7
• Molecular Formula: C₁₃H₉ClF₃N₅
• Molecular Weight: 327.696

Synonyms:3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile

Chemical Property of 3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile

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Technology Process of 3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile

There total 1 articles about 3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-amino-3-chlorobenzonitrile (21803-75-8) + 2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine (515824-43-8) → 3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile (1401423-45-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 18h; Sonication; Microwave irradiation; Sealed tube; Inert atmosphere;

DOI:10.1021/jm301020q

Reference yield: 85.0%

3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile (1401423-45-7) → N2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1401423-46-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 125 ℃; for 18h;

Reference yield: 85.0%

3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzonitrile (1401423-45-7) → N2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1401423-46-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 125 ℃; for 18h;

DOI:10.1021/jm301020q

upstream raw materials:

4-amino-3-chlorobenzonitrile

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine

Downstream raw materials:

N²-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

N²-(2-chloro-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

N₂-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

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