3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

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Chemical Name:3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide
CAS No.:1309363-72-1
Molecular Formula:C₂₆H₃₀N₄O₂
Molecular Weight:430.55
Hs Code.:

Synonyms:3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

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Chemical Property of 3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

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Technology Process of 3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

There total 12 articles about 3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₈N₄O₂

: 1309363-72-1
3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

Guidance literature:: C₃₀H₃₈N₄O₂; With trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; for 1.33333h; Reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1309363-72-1
3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 9 steps

1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

3: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

5: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

6: water / methanol / 0.75 h / Reflux

7: Knorr's reagent / 1-methyl-pyrrolidin-2-one; ethanol / 0.08 h

8: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 0.67 h

9: trifluoroacetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 1.33 h / Reflux

With water; hydrogen; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1309363-72-1
3-(2-amino-6-(2-methyl-6-(pyrrolidine-1-carbonyl)phenyl)quinolin-3-yl)-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 130 °C / Sealed tube

2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C

4: potassium acetate / palladium diacetate; XPhos / ethanol; water / 0.5 h / 145 °C / microwave irradiation

5: water / methanol / 0.75 h / Reflux

6: Knorr's reagent / 1-methyl-pyrrolidin-2-one; ethanol / 0.08 h

7: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 0.67 h

8: trifluoroacetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 1.33 h / Reflux

With water; hydrogen; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; acetonitrile;