(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

Base Information

Chemical Name:(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide
CAS No.:1407512-87-1
Molecular Formula:C₅₃H₇₄N₈O₂
Molecular Weight:855.223
Hs Code.:

Synonyms:(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

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Chemical Property of (S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

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Technology Process of (S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

There total 4 articles about (S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1407512-86-0
(S)-N-(2-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-1-(octadecylcarbamoyl)ethyl)carbamic acid tert-butyl ester

: 1407512-87-1
(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 16h; Cooling with ice;
DOI:10.1002/anie.201205701 DOI:10.1002/anie.201205701

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 1407512-87-1
(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; toluene / 0.75 h / Cooling with ice

1.2: 22 h / 60 °C

2.1: sodium hydroxide / water; isopropyl alcohol / 80 °C / pH 8

2.2: 17 h / Reflux

3.1: hydrogenchloride / dichloromethane; diethyl ether / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1002/anie.201205701 DOI:10.1002/anie.201205701

Reference yield:

: 777952-61-1
(S)-[2-(4-hydroxyphenyl)-1-(octadecylcarbamoyl)ethyl]carbamic acid tert-butyl ester

: 1407512-87-1
(S)-2-amino-3-{3,5-bis[((bis(pyridin-2-ylmethyl)amino)methyl)]-4-hydroxyphenyl}-N-octadecylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; isopropyl alcohol / 80 °C / pH 8

1.2: 17 h / Reflux

2.1: hydrogenchloride / dichloromethane; diethyl ether / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium hydroxide; In diethyl ether; dichloromethane; water; isopropyl alcohol;
DOI:10.1002/anie.201205701 DOI:10.1002/anie.201205701