(1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one

Base Information

• Chemical Name: (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one
• CAS No.: 185542-15-8
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348

Synonyms:(1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one

Chemical Property of (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one

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Technology Process of (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one

There total 2 articles about (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) + pseudo-meso-5-hydroxy-endo-tricyclo<5.2.1.02,6>deca-4,8-dien-3-one (39167-09-4,53660-82-5) + methyl iodide (74-88-4) → (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.02,6]deca-4,8-dien-3-one (185542-15-8)

Guidance literature:

(2S)-2-(methoxymethyl)-1-pyrrolidine; pseudo-meso-5-hydroxy-endo-tricyclo<5.2.1.0^2,6>deca-4,8-dien-3-one; In toluene; for 42h; Heating;

methyl iodide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(01)01007-9

Reference yield:

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) + pseudo-meso-5-hydroxy-endo-tricyclo<5.2.1.02,6>deca-4,8-dien-3-one (39167-09-4,53660-82-5) → (3aS,4R,7S,7aR)-3-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one (185542-11-4) + (1R,2S,6R,7S,2'S)-5-(2'-methoxymethylpyrrolidin-1'-yl)-endo-tricyclo[5.2.1.02,6]deca-4,8-dien-3-one (185542-15-8)

Guidance literature:

In toluene; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/0040-4039(96)01810-2

upstream raw materials:

(2S)-2-(methoxymethyl)-1-pyrrolidine

pseudo-meso-5-hydroxy-endo-tricyclo<5.2.1.0^2,6>deca-4,8-dien-3-one

methyl iodide

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