[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine

Base Information

• Chemical Name: [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine
• CAS No.: 511256-31-8
• Molecular Formula: C₁₉H₁₉F₆N
• Molecular Weight: 375.357
• Mol file: 511256-31-8.mol

Synonyms:[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine

Chemical Property of [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine

There total 4 articles about [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine (384824-41-3) + methyl iodide (74-88-4) → [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine (511256-31-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 58 ℃; for 43h;

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine (511256-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc chloride / toluene / 15 h / Heating

2: sodium borohydride / methanol / 12 h / 0 °C

3: potassium carbonate / dimethylformamide / 24 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; zinc(II) chloride; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol034014w

Reference yield:

3,5-bis(trifluoromethyl)phenyl methyl ketone (30071-93-3) → [(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-methyl-((S)-1-phenyl-ethyl)-amine (511256-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc chloride / toluene / 15 h / Heating

2: sodium borohydride / methanol / 12 h / 0 °C

3: potassium carbonate / dimethylformamide / 24 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; zinc(II) chloride; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol034014w

upstream raw materials:

[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine

methyl iodide

(S)-1-phenyl-ethylamine

3,5-bis(trifluoromethyl)phenyl methyl ketone

Downstream raw materials:

(S)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine