(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Base Information

Chemical Name:(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate
CAS No.:1449786-48-4
Molecular Formula:C₂₇H₃₆N₄O₇
Molecular Weight:528.605
Hs Code.:

Synonyms:(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Suppliers and Price of (2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

There total 4 articles about (2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3373-59-9
L-threonine methyl ester

: 1449786-45-1
(S)-4-amino-3-(2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzoic acid

: 1449786-48-4
(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 1449786-44-0
(S)-methyl 4-amino-3-(2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzoate

: 1449786-48-4
(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 36692-49-6
Methyl 3,4-diaminobenzoate

: 1449786-48-4
(2S,3R)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido) benzamido)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

2: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024