3373-59-9Relevant articles and documents
Clickable glycopeptoids for synthesis of glycopeptide mimic
Singhamahapatra, Anadi,Sahoo, Laxminarayan,Loganathan, Duraikkannu
, p. 10329 - 10336 (2013)
Structurally diverse novel glycopeptoids were synthesized which can be attached to biologically important peptides by click reaction to improve their potential to be used in medicinal chemistry. Triazole-linked αβ-hydrid glycopeptoids were synthesized that mimic the conserved linkage region of N-linked glycoproteins in eukaryotes. The amide bonds were replaced with triazole rings, and αβ-hybrid peptoids were introduced as the backbone modification in peptidomimetics. In addition to their facile synthesis, these modifications have the possibility of introducing otherwise impossible conformations in the peptide backbone.
Synthesis of Ethyl cis-2--7-oxo-3-phenyl-6-phthalimido-1-azabicyclohept-3-ene-2-carboxylate and Methyl cis-2-Bromo-3-methyl-8-oxo-7-phthalimido-4-oxa-1-azabicyclooctane-2-carboxylate
Hakimelahi, Gholam H.,Jarrahpour, Ali A.
, p. 1501 - 1505 (1989)
Th synthesis of Δ1-carbapenem and two β-lactams possessing a Br-atom at the N-substituting center not involved in the lactam ring and bearing the carboxyl group is described.The β-lactams having this kind of Br-substitution are more susceptible to nucleophilic attack than those having a conjugated double bond with the N-atom of the β-lactam ring.DBU is found to be an excellent reagent for the elimination of the silyloxy function.Moreover, a simple method for the addition of diethyl phosphite to an α,β-unsaturated double bond using a catalytic amount of NaH is described.
Visible-Light Mediated Tryptophan Modification in Oligopeptides Employing Acylsilanes
Reimler, Jannik,Studer, Armido
supporting information, p. 15392 - 15395 (2021/10/04)
A method for the selective tryptophan modification and labelling of tryptophan-containing peptides is described. Photoirradiation of acylsilanes generates reactive siloxycarbenes which undergo H?N-insertion into the indole moiety of tryptophan to give stable silyl protected hemiaminals. This method is successfully applied to chemically modify various tryptophan containing oligopeptides. The method enables the selective introduction of alkynes to peptides that are eligible for further alkyne-azide click chemistry. In addition, the dansyl fluorophore can be conjugated to a peptide using this approach.
NOVEL TRITERPENE DERIVATIVES AS HIV INHIBITORS
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Page/Page column 34, (2020/08/28)
The present invention relates to novel triterpene derivatives of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and ring are as defined herein. The invention also relates to novel triterpene derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
