3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Base Information

Chemical Name:3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS No.:1259080-05-1
Molecular Formula:C₁₇H₁₅FN₂O₂
Molecular Weight:298.317
Hs Code.:

Synonyms:3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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Chemical Property of 3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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Technology Process of 3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

There total 6 articles about 3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259080-04-0
3-(3-fluorophenyl)-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carbaldehyde

: 75-16-1
methylmagnesium bromide

: 1259080-05-1
3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: 3-(3-fluorophenyl)-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carbaldehyde; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 5h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1259079-96-3
(3-bromo-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

: 1259080-05-1
3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; 1,4-dioxane / 3 h / 70 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 1 h / 100 °C / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

3.2: 2 h / -78 - 15 °C

4.1: tetrahydrofuran / 5 h / 10 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1259079-94-1
3-bromo-2-(chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

: 1259080-05-1
3-(3-fluorophenyl)-2-(1-hydroxyethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 3.5 h / 40 °C

2.1: hydrogenchloride / water; 1,4-dioxane / 3 h / 70 °C

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 1 h / 100 °C / Inert atmosphere

4.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

4.2: 2 h / -78 - 15 °C

5.1: tetrahydrofuran / 5 h / 10 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium acetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;