4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

Base Information

Chemical Name:4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide
CAS No.:1610372-95-6
Molecular Formula:C₂₄H₃₄N₂O₄Si
Molecular Weight:442.63
Hs Code.:

Synonyms:4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

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Chemical Property of 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

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Technology Process of 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

There total 7 articles about 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1253926-81-6
N,N,3-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1610372-27-4
6-bromo-5-(2-((tert-butyldimethylsilyl)-oxy)ethoxy)picolinaldehyde

: 1610372-95-6
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; at 80 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610372-95-6
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 15 h / 80 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; potassium carbonate; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610372-95-6
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 15 h / 80 °C / Inert atmosphere; Sealed tube

With ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; potassium carbonate; potassium hydroxide; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;