(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

Base Information

Chemical Name:(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate
CAS No.:869899-71-8
Molecular Formula:C₂₆H₂₅Cl₂NO₅S
Molecular Weight:534.46
Hs Code.:

(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

Synonyms:(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

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Chemical Property of (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

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Technology Process of (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

There total 5 articles about (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869899-64-9
3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylic acid

: 79-50-5,599-04-2,5405-40-3,52126-90-6
(S)-pantolactone

: 869899-71-8
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

Guidance literature:: 3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylic acid; (S)-pantolactone; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 358749-82-3
2-amino-4,5,6,7-tetrahydro-3-(4-methoxybenzoyl)-1-benzothiophene-6-carboxylic acid ethyl ester

: 869899-71-8
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / tetrahydrofuran / 1.58 h / 0 °C / Heating / reflux

2: hydrogenchloride; water / acetic acid / 5 h / 92 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C

With hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; aluminum (III) chloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); acetic acid;

Reference yield:

: 121-98-2
methyl 4-methoxybenzoate

: 869899-71-8
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (7S)-3-chloro-2-chloromethyl-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / dimethyl sulfoxide / 2 h / 110 °C

1.2: 15 °C

1.3: 20 °C / pH 7.9

2.1: morpholine; sulfur / ethanol / 3 h / Heating / reflux

3.1: aluminum (III) chloride / tetrahydrofuran / 1.58 h / 0 °C / Heating / reflux

4.1: hydrogenchloride; water / acetic acid / 5 h / 92 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C

With morpholine; hydrogenchloride; dmap; water; sodium methylate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; aluminum (III) chloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; acetic acid; dimethyl sulfoxide;