(4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene

Base Information

• Chemical Name: (4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene
• CAS No.: 124754-56-9
• Molecular Formula: C₂₁H₃₁ClN₂O₄
• Molecular Weight: 410.941

Synonyms:(4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene

Chemical Property of (4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene

There total 3 articles about (4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4S)-N8-(benzyloxycarbonyl)-N4-(tert-butoxycarbonyl)-4,8-diamino-2-octene-1-ol (124754-93-4) → (4S)-N8-(benzyloxycarbonyl)-N4-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene (124754-56-9)

Guidance literature:

With N-chloro-succinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

(E)-(S)-8-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-oct-2-enoic acid methyl ester (124755-01-7) → (4S)-N8-(benzyloxycarbonyl)-N4-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene (124754-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BF₃*Et₂O, 2.) i-Bu₂AlH / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) hexane, 1 h

2: 100 percent / Ph₃P, N-chlorosuccinimide / CH₂Cl₂ / 1 h / 0 °C

With N-chloro-succinimide; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triphenylphosphine; In dichloromethane;

Reference yield:

benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate (82689-16-5) → (4S)-N8-(benzyloxycarbonyl)-N4-(tert-butoxycarbonyl)-4,8-diamino-1-chloro-2-octene (124754-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / benzene / 16 h / Ambient temperature

2: 1.) BF₃*Et₂O, 2.) i-Bu₂AlH / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) hexane, 1 h

3: 100 percent / Ph₃P, N-chlorosuccinimide / CH₂Cl₂ / 1 h / 0 °C

With N-chloro-succinimide; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triphenylphosphine; In dichloromethane; benzene;

upstream raw materials:

(4S)-N⁸-(benzyloxycarbonyl)-N⁴-(tert-butoxycarbonyl)-4,8-diamino-2-octene-1-ol

(E)-(S)-8-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-oct-2-enoic acid methyl ester

benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate

Downstream raw materials:

(4S,5R)-4-<<(N-benzyloxycarbonyl)amino>butyl>-5-vinyl-2-oxazolidinone

(4S,5S)-4-<<(N-benzyloxycarbonyl)amino>butyl>-5-vinyl-2-oxazolidinone

C₂₃H₃₇ClN₂O₄Si

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