Ethyl alpha-oxofuran-2-acetate

Base Information

• Chemical Name: Ethyl alpha-oxofuran-2-acetate
• CAS No.: 1639-37-8
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Hs Code.: 2932190090
• European Community (EC) Number: 216-680-9
• UNII: ZVA5L8EED7
• DSSTox Substance ID: DTXSID50167677
• Nikkaji Number: J195.275G
• Wikidata: Q83037090
• Mol file: 1639-37-8.mol

Synonyms:ethyl 2-(furan-2-yl)-2-oxoacetate;1639-37-8;Ethyl alpha-oxofuran-2-acetate;2-Furanacetic acid, alpha-oxo-, ethyl ester;EINECS 216-680-9;Furan-2-yl-oxo-acetic acid ethyl ester;Ethyl 2-furanglyoxylate;starbld0038540;Ethyl furan-2-glyoxylate;ZVA5L8EED7;Ethyl (2-furyl)glyoxalate;SCHEMBL986419;Ethyl alpha-oxo-2-furanacetate;DTXSID50167677;BAA63937;AKOS006286410;alpha-Oxo-2-furanacetic acid ethyl ester;2-(2-FURYL)-2-OXOACETIC ACID ETHYL ESTER

Chemical Property of Ethyl alpha-oxofuran-2-acetate

Chemical Property:

• Vapor Pressure: 0.0584mmHg at 25°C
• Melting Point: 27-29 °C
• Boiling Point: 232.6°Cat760mmHg
• Flash Point: 94.5°C
• PSA: 56.51000
• Density: 1.198g/cm³
• LogP: 1.02540
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 168.04225873
• Heavy Atom Count: 12
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

2-(2-FURYL)-2-OXOACETICACIDETHYLESTER ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C(=O)C1=CC=CO1

Technology Process of Ethyl alpha-oxofuran-2-acetate

There total 6 articles about Ethyl alpha-oxofuran-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

furan-2-yl-oxo-acetic acid (1467-70-5) + ethanol (64-17-5) → ethyl α-keto-(2-furyl)acetate (1639-37-8)

Guidance literature:

With sulfuric acid; In chloroform; for 10h; Heating;

DOI:10.1016/S0957-4166(03)00158-7

Reference yield: 75.0%

furan-2-yl-oxo-acetic acid (1467-70-5) → ethyl α-keto-(2-furyl)acetate (1639-37-8)

Guidance literature:

DOI:10.1016/S0040-4039(98)02594-5

Reference yield: 61.0%

ethanol (64-17-5) + 1-(2-furyl)-2-nitro-1-ethanone → ethyl α-keto-(2-furyl)acetate (1639-37-8)

Guidance literature:

With 1-[4-(diacetoxyiodo)benzyl]-3-methylimidazolium tetrafluoroborate; for 1h; Reflux;

DOI:10.1055/s-0035-1562535

upstream raw materials:

ethyl 2-(furan-2-yl)-2-hydroxyacetate

furan-2-yl-oxo-acetic acid

ethanol

furan

Downstream raw materials:

(Z)-ethyl 2-[(benzyloxy)imino]-2-(2-furyl)acetate

(E)-ethyl 2-[(benzyloxy)imino]-2-(2-furyl)acetate

(S)-2-amino-2-(furan-2'yl)-ethanol