N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide

Base Information

Chemical Name:N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide
CAS No.:24477-36-9
Molecular Formula:C₁₃H₁₅N₃O₄S
Molecular Weight:309.346
Hs Code.:
Mol file:24477-36-9.mol

Synonyms:4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid

Suppliers and Price of N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-3-carboxamide
25mg
$ 145.00

Total 1 raw suppliers

Chemical Property of N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide

Chemical Property:

Purity/Quality:: 5-Methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-3-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-Methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-3-carboxamide is a reagent used for the synthesis of glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.

Technology Process of N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide

There total 7 articles about N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-3-isoxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 85-44-9
phthalic anhydride

: 25046-79-1
glisoxepide

: N-(1-Azepinyl)phthalimid

: 24477-36-9
4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid

Guidance literature:: With pyridine; dmap; for 4h; Heating;
DOI:10.1002/ardp.19863190803

Reference yield: 50.0%

: 25046-79-1
glisoxepide

: N-(1-Azepinyl)phthalimid

: 24477-36-9
4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid

Guidance literature:: With pyridine; dmap; phthalic anhydride; for 4h; Heating;
DOI:10.1002/ardp.19863190803

Reference yield: 48.0%

: 39499-34-8
5-methyl-3-isoxazolyl chloride

: 35303-76-5
4-(2-aminoethyl)benzenesulfonamide

: 24477-36-9
4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid

Guidance literature:: 5-methyl-3-isoxazolyl chloride; With triethylamine; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

4-(2-aminoethyl)benzenesulfonamide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;