Glisoxepide

Base Information

• Chemical Name: Glisoxepide
• CAS No.: 25046-79-1
• Molecular Formula: C20H27 N5 O5 S
• Molecular Weight: 449.531
• European Community (EC) Number: 246-579-5
• UNII: H7SC0I332I
• DSSTox Substance ID: DTXSID9023097
• Nikkaji Number: J20.337H
• Wikipedia: Glisoxepide
• Wikidata: Q5569932
• NCI Thesaurus Code: C72801
• Pharos Ligand ID: B9AUX1GJZ8BW
• Metabolomics Workbench ID: 43482
• ChEMBL ID: CHEMBL2106618
• Mol file: 25046-79-1.mol

Synonyms:4-(4-beta-(5-methylisoxazol-3-carboxamidoethyl)phenylsulfonyl)-1,1-hexamethylenesemicarbazide;BS 4231;BS-4231;glisoxepid;glisoxepide;Pro-diaban;RP 22410;RP-22410

Chemical Property of Glisoxepide

Chemical Property:

• Melting Point: 189°
• Refractive Index: 1.6460 (estimate)
• Boiling Point: °Cat760mmHg
• PKA: 5.92±0.10(Predicted)
• Flash Point: °C
• PSA: 142.02000
• Density: 1.37g/cm³
• LogP: 3.92580
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 449.17329015
• Heavy Atom Count: 31
• Complexity: 697

Purity/Quality:

98%Min ^*data from raw suppliers

Glisoxepid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NO1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NN3CCCCCC3
• Uses: Labelled Glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.
• Therapeutic Function: Oral hypoglycemic

Technology Process of Glisoxepide

There total 5 articles about Glisoxepide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-3-isoxazolyl chloride (39499-34-8) → glisoxepide (25046-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: butan-2-one

3: 1,2-dimethoxy-ethane

In pyridine; 1,2-dimethoxyethane; butanone;

Reference yield:

chlorhydrate de (β-aminoethyl)-4 benzenesulfonamide (6325-22-0,42286-14-6) → glisoxepide (25046-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: butan-2-one

3: 1,2-dimethoxy-ethane

In pyridine; 1,2-dimethoxyethane; butanone;

Reference yield:

4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid (24477-36-9) → glisoxepide (25046-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: butan-2-one

2: 1,2-dimethoxy-ethane

In 1,2-dimethoxyethane; butanone;

upstream raw materials:

1-azepanylamine

{4-[2-(5-methyl-isoxazole-3-carbonylamino)-ethyl]-benzenesulfonyl}-carbamic acid methyl ester

5-methyl-3-isoxazolyl chloride

chlorhydrate de (β-aminoethyl)-4 benzenesulfonamide

Downstream raw materials:

4-<2-(5-Methyl-3-isoxazolcarboxamido)ethyl>benzolsulfonamid

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