6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Base Information

• Chemical Name: 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide
• CAS No.: 1215082-85-1
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 1215082-85-1.mol

Synonyms:6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Chemical Property of 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

There total 3 articles about 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide (1215082-84-0) + potassium phtalimide (1074-82-4) → 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide (1215082-85-1)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.12.066

Reference yield:

6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine (638133-16-1) → 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide (1215082-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; acetic acid; triethylamine / dichloromethane / 0.75 h / -78 - -30 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With iodine; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.04.078

Reference yield:

6,6-dimethyl-5,6-dihydro-3-methyl-4-phenyl-1,2-oxazine N-oxide (638133-04-7) → 6,6-dimethyl-3-(phthalimidomethyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide (1215082-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / -78 °C / Inert atmosphere

2: iodine; acetic acid; triethylamine / dichloromethane / 0.75 h / -78 - -30 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With iodine; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.04.078

upstream raw materials:

3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

potassium phtalimide

6,6-dimethyl-5,6-dihydro-3-methyl-4-phenyl-1,2-oxazine N-oxide

6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine