3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Base Information

Chemical Name:3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide
CAS No.:1215082-84-0
Molecular Formula:C₁₃H₁₆INO₂
Molecular Weight:345.18
Hs Code.:

Synonyms:3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

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Chemical Property of 3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

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Technology Process of 3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

There total 2 articles about 3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 638133-16-1
6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine

: 1215082-84-0
3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Guidance literature:: 6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine; With acetic acid; triethylamine; In dichloromethane; at -94 ℃; for 0.0833333h; Inert atmosphere;

With iodine; In dichloromethane; at -94 - -30 ℃; for 0.916667h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.12.066

Reference yield:

: 638133-04-7
6,6-dimethyl-5,6-dihydro-3-methyl-4-phenyl-1,2-oxazine N-oxide

: 1215082-84-0
3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / -78 °C / Inert atmosphere

2: iodine; acetic acid; triethylamine / dichloromethane / 0.75 h / -78 - -30 °C / Inert atmosphere

With iodine; acetic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2011.04.078

Reference yield: 90.0%

: 1215082-84-0
3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

: 1313227-89-2
C₁₃H₁₇NO₂

Guidance literature:: 3-(iodomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide; With lithium phenylacetylide; In tetrahydrofuran; hexane; at -60 - 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; diethyl ether; hexane; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.078