acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

Base Information

Chemical Name:acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester
CAS No.:1380646-25-2
Molecular Formula:C₂₃H₂₂FN₃O₅S
Molecular Weight:471.509
Hs Code.:

Synonyms:acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

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Chemical Property of acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

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Technology Process of acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

There total 8 articles about acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1380646-44-5
3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

: 1380646-62-7
acetic acid 5-amino-pyrazin-2-ylmethyl ester trifluoroacetate

: 1380646-25-2
acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 90536-66-6
4-(methylsulfonyl)phenylacetic acid

: 1380646-25-2
acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tert-butyl alcohol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 5521-55-1
2-methylpyrazin-5-carboxylic acid

: 1380646-25-2
acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 3 h / 100 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 4 h / 100 °C

3: 18-crown-6 ether; potassium acetate / acetonitrile / 72 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; N-Bromosuccinimide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; tetrachloromethane; dichloromethane; acetonitrile;