3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

Base Information

• Chemical Name: 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid
• CAS No.: 1380646-44-5
• Molecular Formula: C₁₆H₁₅FO₄S
• Molecular Weight: 322.357
• Mol file: 1380646-44-5.mol

Synonyms:3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

Chemical Property of 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

There total 4 articles about 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionic acid tert-butyl ester (1380646-43-4) → 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid (1380646-44-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 83.0%

3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)-propionic acid methyl ester (1380646-45-6) → 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid (1380646-44-5)

Guidance literature:

3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)-propionic acid methyl ester; With water; potassium hydroxide; In ethanol; at 20 ℃;

With hydrogenchloride; In dichloromethane; water; pH=1 - 2;

Reference yield:

4-(methylsulfonyl)phenylacetic acid (90536-66-6) → 3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid (1380646-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap / tert-butyl alcohol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

upstream raw materials:

4-(methylsulfonyl)phenylacetic acid

(4-methanesulfonyl-phenyl)-acetic acid methyl ester

3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionic acid tert-butyl ester

3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)-propionic acid methyl ester

Downstream raw materials:

3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(5-methylsulfanyl-pyrazin-2-yl)-propionamide

N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(5-methyl-pyrazin-2-yl)-propionamide

5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)propionylamino]-pyrazine-2-carboxylic acid methyl ester