tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

Base Information

Chemical Name:tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate
CAS No.:1237147-96-4
Molecular Formula:C₂₈H₃₂FN₃O₃S
Molecular Weight:509.645
Hs Code.:

Synonyms:tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

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Chemical Property of tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

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Technology Process of tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

There total 7 articles about tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237147-81-7
4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoic acid

: 39181-55-0
2-amino-5-(4-fluorobenzyl)-1,3,4-thiadiazole

: 1237147-96-4
tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 144h;

Reference yield:

: 1237147-83-9
ethyl 4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoate

: 1237147-96-4
tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 144 h / 20 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 39203-09-3
2-[(4-fluorophenyl)acetyl]hydrazinecarbothioamide

: 1237147-96-4
tert-butyl (4-{4-[5-(4-fluorobenzyl)[1.3.4]thiadiazol-2-ylcarbamoyl]-phenyl}cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 3 h / -10 - 0 °C

1.2: -10 - 0 °C

2.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 144 h / 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;