1-(6-Bromopyridin-2-yl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(6-Bromopyridin-2-yl)-4-methylpiperazine
• CAS No.: 153976-27-3
• Molecular Formula: C₁₀H₁₄BrN₃
• Molecular Weight: 256.145
• DSSTox Substance ID: DTXSID90598587
• Wikidata: Q82494361
• Mol file: 153976-27-3.mol

Synonyms:1-(6-bromopyridin-2-yl)-4-methylpiperazine;153976-27-3;6-(4-METHYLPIPERAZIN-1-YL)-2-BROMOPYRIDINE;SCHEMBL421349;DTXSID90598587;WLZ3020;KEYDJYZYBWRMLD-UHFFFAOYSA-N;MFCD00925756;AKOS013278962;AB07691;SY288871;DB-311139;1-(6-bromo-2-pyridyl)-4-methyl piperazine;CS-0447229;E86196;A1-16926;J-503449;6-(4-methylpiperazin-1-yl)-2-bromopyridine, AldrichCPR;F1967-3372

Chemical Property of 1-(6-Bromopyridin-2-yl)-4-methylpiperazine

Chemical Property:

• Boiling Point: 356.2±42.0 °C(Predicted)
• PKA: 7.12±0.42(Predicted)
• Density: 1.406±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 255.03711
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

98%min ^*data from raw suppliers

1-(6-Bromopyridin-2-yl)-4-methylpiperazine 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: CN1CCN(CC1)C2=NC(=CC=C2)Br

Technology Process of 1-(6-Bromopyridin-2-yl)-4-methylpiperazine

There total 1 articles about 1-(6-Bromopyridin-2-yl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-methyl-piperazine (109-01-3) + 2,6-Dibromopyridine (626-05-1) → 1-(6-bromopyridin-2-yl)-4-methylpiperazine (153976-27-3)

Guidance literature:

With potassium phosphate; In 1,4-dioxane; at 105 ℃; for 16h; Inert atmosphere;

Reference yield: 100.0%

1-(6-bromopyridin-2-yl)-4-methylpiperazine (153976-27-3) + bis(2,5-dimethoxyphenyl)zinc (1256169-21-7) → 1-(6-(2,5-dimethoxyphenyl)pyridin-2-yl)-4-methylpiperazine (1309609-91-3)

Guidance literature:

With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In 1-methyl-pyrrolidin-2-one; toluene; at 100 ℃; for 0.25h;

DOI:10.1002/adsc.201000942

Reference yield: 99.0%

1-(6-bromopyridin-2-yl)-4-methylpiperazine (153976-27-3) + 4-methoxyphenylboronic acid (5720-07-0) → 1-(6-(4-methoxyphenyl)pyridin-2-yl)-4-methylpiperazine (1309609-60-6)

Guidance literature:

With potassium phosphate; dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In toluene; at 80 ℃; for 0.25h;

DOI:10.1002/adsc.201000942

upstream raw materials:

1-methyl-piperazine

2,6-Dibromopyridine

Downstream raw materials:

benzyl 2-(6-(4-methylpiperazin-1-yl)pyridin-2-yl)ethylcarbamate

1-(6-(2,5-dimethoxyphenyl)pyridin-2-yl)-4-methylpiperazine

1-(6-(4-methoxyphenyl)pyridin-2-yl)-4-methylpiperazine

N,N-dimethyl-4-(6-(4-methylpiperazin-1-yl)pyridin-2-yl)aniline