(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

Base Information

Chemical Name:(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine
CAS No.:196500-31-9
Molecular Formula:C₃₁H₃₇N₅O₅
Molecular Weight:559.665
Hs Code.:

Synonyms:(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Chemical Property of (4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Technology Process of (4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

There total 9 articles about (4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-14-5
Boc-Trp-OH

: (4aR,5S)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

: 196500-31-9
(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 193203-27-9
IQM 95333

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1021/jm9703247

Reference yield:

: 13139-14-5
Boc-Trp-OH

: 1053644-74-8
(4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

: 196500-31-9
(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 193203-27-9
IQM 95333

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 12h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1021/jm9703247

Reference yield:

: 3173-56-6
benzyl isothiocyanate

: 196500-31-9
(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1 h / Ambient temperature

2: NaH / tetrahydrofuran / 3 h / Ambient temperature

3: TFA / CH₂Cl₂ / 4 h / Ambient temperature

4: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9703247