(4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Base Information

• Chemical Name: (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione
• CAS No.: 1053644-74-8
• Molecular Formula: C₁₅H₁₉N₃O₂
• Molecular Weight: 273.335
• Mol file: 1053644-74-8.mol

Synonyms:(4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Chemical Property of (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

There total 4 articles about (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4aS,5R)-2-Benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-yl)-carbamic acid tert-butyl ester → (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione (1053644-74-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1021/jm9703247

Reference yield:

benzyl isothiocyanate (3173-56-6) → (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione (1053644-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / tetrahydrofuran / 1 h / Ambient temperature

2: 76 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

3: TFA / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9703247

Reference yield:

((2S,3R)-3-tert-Butoxycarbonylamino-piperidin-2-yl)-acetic acid ethyl ester (1219132-56-5) → (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione (1053644-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / tetrahydrofuran / 1 h / Ambient temperature

2: 76 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

3: TFA / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9703247

upstream raw materials:

benzyl isothiocyanate

((2S,3R)-3-tert-Butoxycarbonylamino-piperidin-2-yl)-acetic acid ethyl ester

Downstream raw materials:

(4aR,5S)-2-benzyl-5-(Boc-L-tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

IQM 95333