methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate

Base Information

• Chemical Name: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate
• CAS No.: 1292323-11-5
• Molecular Formula: C₂₃H₂₈NO₅P
• Molecular Weight: 429.453
• Mol file: 1292323-11-5.mol

Synonyms:methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate

Chemical Property of methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate

There total 1 articles about methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimethyl (2-formyl-2-methyl-1-phenylcyclopropyl)phosphonate + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate (1292323-11-5)

Guidance literature:

With sodium sulfate; In dichloromethane; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.02.068

Reference yield:

methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate (1292323-11-5) → (2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate (1292323-13-7) + (2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate (1292323-13-7)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In methanol; at 20 ℃; for 1.5h;

DOI:10.1016/j.tet.2011.02.068

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

Downstream raw materials:

(2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate

(2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate