(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester
CAS No.:177957-93-6
Molecular Formula:C₃₄H₄₂Cl₃NO₆Si
Molecular Weight:695.155
Hs Code.:

(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Synonyms:(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Suppliers and Price of (4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 12 articles about (4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 77-76-9
2,2-dimethoxy-propane

: 177957-92-5
[(1R,2S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-hydroxy-3-(4-methoxy-benzyloxy)-propyl]-carbamic acid 2,2,2-trichloro-ethyl ester

: 177957-93-6
(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In acetone; Ambient temperature;
DOI:10.1016/0040-4039(96)00594-1

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 177957-93-6
(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / NaH / paraffin; dimethylformamide / 3 h / Ambient temperature

2: L-(+)-DET, Ti(O-i-Pr)4, TBHP, molecular sieves / CH₂Cl₂; 2,2,4-trimethyl-pentane / 70 h / -20 °C

3: 55 percent / NaN₃, NH₄Cl / ethanol / 17 h / Heating

4: 91 percent / Et₃N, DMAP / CH₂Cl₂ / 17 h / Ambient temperature

5: Ph₃P / tetrahydrofuran; H₂O / 17 h / Ambient temperature

6: aq. NaHCO₃ / 0.5 h / Ambient temperature

7: 97 percent / TsOH / acetone / 21 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium azide; molecular sieve; diethyl (2R,3R)-tartrate; sodium hydride; sodium hydrogencarbonate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; 2,2,4-trimethylpentane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; paraffin;
DOI:10.1016/S0040-4020(97)00651-0

Reference yield:

: 177957-84-5
(2S,3S)-3-(O-benzyl)-4-[O-(p-methoxy)benzyl]-1,2,3,4-butanetetraol-1,2-di-O-acetonide

: 177957-93-6
(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / H₂ / Raney Ni / ethanol / 1 h / 760 Torr / Ambient temperature

2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 97 percent / aq. HCl / methanol / 0.5 h / Ambient temperature

4: 88 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

5: 55 percent / NaN₃, NH₄Cl / ethanol / 17 h / Heating

6: 91 percent / Et₃N, DMAP / CH₂Cl₂ / 17 h / Ambient temperature

7: Ph₃P / tetrahydrofuran; H₂O / 17 h / Ambient temperature

8: aq. NaHCO₃ / 0.5 h / Ambient temperature

9: 97 percent / TsOH / acetone / 21 h / Ambient temperature

With hydrogenchloride; dmap; sodium azide; hydrogen; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(97)00651-0