2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

Base Information

Chemical Name:2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one
CAS No.:1620645-92-2
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

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Technology Process of 2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

There total 6 articles about 2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1620645-59-1
(±)-2-[[3-acetyl-1-(o-tolylmethyl)pyridin-1-ium-4-yl]methyl]-5,6-dimethoxy-indan-1-one bromide

: 1620645-92-2
2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

Guidance literature:: With 1-Benzyl-1,4-dihydronicotinamide; In dichloromethane; at 20 ℃; regioselective reaction; Inert atmosphere; Darkness;
DOI:10.1021/acs.jmedchem.7b00702

Reference yield: 50.0%

: 1620645-92-2
2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

Guidance literature:: With N-benzyl-1,4-dihydronicotinamide; In dichloromethane; at 25 ℃; for 48h; Inert atmosphere;

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1620645-92-2
2-[[3-acetyl-1-(o-tolylmethyl)-4H-pyridin-4-yl]methyl]-5,6-dimethoxy-indan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Dean-Stark

2: hydrogen; 5 % platinum on carbon / ethanol / 3 h / 20 °C / 760.05 Torr / Reflux; Dean-Stark

3: bis(dibenzylideneacetone)-palladium⁽⁰⁾; triphenylphosphine / toluene / 110 °C

4: dichloromethane / 12 h / Reflux

5: 1-Benzyl-1,4-dihydronicotinamide / dichloromethane / 20 °C / Inert atmosphere; Darkness

With 1-Benzyl-1,4-dihydronicotinamide; 5 % platinum on carbon; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b00702