1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

Base Information

Chemical Name:1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone
CAS No.:217654-66-5
Molecular Formula:C₂₁H₂₂F₂N₆O₂
Molecular Weight:428.441
Hs Code.:

Synonyms:1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

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Chemical Property of 1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

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Technology Process of 1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

There total 8 articles about 1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 217654-65-4
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-nitrophenyl)-2-imidazolidinone

: 217654-66-5
1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; ethyl acetate; at 20 ℃; for 3h;
DOI:10.1248/cpb.48.1947

Reference yield:

: 100-28-7
4-Nitrophenyl isocyanate

: 217654-66-5
1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / dimethylsulfoxide / 1 h / 20 °C

2: POCl₃ / ethyl acetate; N,N-dimethyl-acetamide / 16 h / 20 °C

3: Et₃N / ethyl acetate; N,N-dimethyl-acetamide / 2 h / 20 °C

4: 75 percent / H₂ / 10 percent Pd/C / H₂O; ethyl acetate / 3 h / 20 °C

With hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1248/cpb.48.1947

Reference yield:

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 217654-66-5
1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / Ti(O-isoPr)4 / propan-1-ol / 7.5 h / Heating

2: 39 percent / dimethylsulfoxide / 1 h / 20 °C

3: POCl₃ / ethyl acetate; N,N-dimethyl-acetamide / 16 h / 20 °C

4: Et₃N / ethyl acetate; N,N-dimethyl-acetamide / 2 h / 20 °C

5: 75 percent / H₂ / 10 percent Pd/C / H₂O; ethyl acetate / 3 h / 20 °C

With titanium(IV) isopropylate; hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In propan-1-ol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1248/cpb.48.1947