(2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

• Chemical Name: (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• CAS No.: 217654-56-3
• Molecular Formula: C₁₄H₁₈F₂N₄O₂
• Molecular Weight: 312.319

Synonyms:(2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property:

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Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 1 articles about (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2) + ethanolamine (141-43-5) → (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol (217654-56-3)

Guidance literature:

With titanium(IV) isopropylate; In propan-1-ol; for 7.5h; Heating;

DOI:10.1248/cpb.48.1947

Reference yield: 86.0%

phenyl 4-(1H-1-tetrazolyl)phenylcarbamate (217654-45-0) + (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol (217654-56-3) → 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea (217654-58-5)

Guidance literature:

With triethylamine; In ethyl acetate; for 1.5h; Heating;

DOI:10.1248/cpb.48.1947

Reference yield: 39.0%

4-Nitrophenyl isocyanate (100-28-7) + (2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol (217654-56-3) → 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-(4-nitrophenyl)urea (217654-63-2)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1248/cpb.48.1947

upstream raw materials:

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

ethanolamine

Downstream raw materials:

1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-(4-nitrophenyl)urea

1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

1-(4-aminophenyl)-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-imidazolidinone

1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-nitrophenyl)-2-imidazolidinone

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