(R)-benzyl 3-hydroxy-13-methyltetradecanoate

Base Information

• Chemical Name: (R)-benzyl 3-hydroxy-13-methyltetradecanoate
• CAS No.: 221696-02-2
• Molecular Formula: C₂₂H₃₆O₃
• Molecular Weight: 348.526
• Mol file: 221696-02-2.mol

Synonyms:(R)-benzyl 3-hydroxy-13-methyltetradecanoate

Chemical Property of (R)-benzyl 3-hydroxy-13-methyltetradecanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-benzyl 3-hydroxy-13-methyltetradecanoate

There total 1 articles about (R)-benzyl 3-hydroxy-13-methyltetradecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

benzyl bromide (100-39-0) + (R)-3-hydroxy-13-methyltetradecanoic acid (221695-92-7) → (R)-benzyl 3-hydroxy-13-methyltetradecanoate (221696-02-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.7164/antibiotics.52.150

Reference yield: 100.0%

Fmoc-Ile (251316-98-0) + (R)-benzyl 3-hydroxy-13-methyltetradecanoate (221696-02-2) → Benzyl 13-methyl-(R)-3-(Fmoc-Ile-O)-tetradecanoate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.7164/antibiotics.52.150

Reference yield:

(R)-benzyl 3-hydroxy-13-methyltetradecanoate (221696-02-2) → (R)-3-(2-Amino-3-methyl-pentanoyloxy)-13-methyl-tetradecanoic acid benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 4-Dimethylaminopyridine; Dicyclohehylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

2: 90 percent / Et₂NH / dimethylformamide / 1 h / 20 °C

With dmap; diethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrolysis;

DOI:10.7164/antibiotics.52.150

upstream raw materials:

benzyl bromide

(R)-3-hydroxy-13-methyltetradecanoic acid