Technology Process of N-[4-(4-nitrophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane
There total 7 articles about N-[4-(4-nitrophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm0101904
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 6 N aq. HCl / 6 h / Heating
2.1: POCl3 / 4 h / Heating
3.1: 7.80 g / -40 - 20 °C
4.1: 49 percent / diethyl ether / 2 h / -40 °C
5.1: Na2CO3; 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / Heating
5.2: 86 percent / MeOH / 20 °C
6.1: 94 percent / K2CO3 / dimethylformamide
With
hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; sodium carbonate; potassium carbonate; trichlorophosphate;
In
diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101904
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 49 percent / diethyl ether / 2 h / -40 °C
2.1: Na2CO3; 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / Heating
2.2: 86 percent / MeOH / 20 °C
3.1: 94 percent / K2CO3 / dimethylformamide
With
carbonochloridic acid 1-chloro-ethyl ester; sodium carbonate; potassium carbonate;
In
diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101904
