(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

Base Information

Chemical Name:(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile
CAS No.:1416146-08-1
Molecular Formula:C₂₈H₃₁FN₄O
Molecular Weight:458.579
Hs Code.:

Synonyms:(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

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Chemical Property of (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

Chemical Property:

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Technology Process of (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

There total 7 articles about (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416146-34-3
(R)-5-bromo-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

: 1765-93-1
4-fluoroboronic acid

: 1416146-08-1
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 5782-69-4
6-isopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1416146-08-1
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

2: triethylamine / dmap / dichloromethane / 2.5 h / 0 - 20 °C

3: triethylamine / acetonitrile / 0.75 h / 175 °C / Microwave irradiation

4: triethylamine / tetrahydrofuran / 4 h / 0 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; potassium carbonate; triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1416146-12-7
5-bromo-6-isopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1416146-08-1
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dmap / dichloromethane / 2.5 h / 0 - 20 °C

2: triethylamine / acetonitrile / 0.75 h / 175 °C / Microwave irradiation

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium carbonate; triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;