(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

Base Information

Chemical Name:(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid
CAS No.:1416146-09-2
Molecular Formula:C₂₈H₃₂FN₃O₃
Molecular Weight:477.579
Hs Code.:

Synonyms:(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

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Chemical Property of (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

Chemical Property:

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Technology Process of (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

There total 8 articles about (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416146-08-1
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile

: 1416146-09-2
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

Guidance literature:: (R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinonitrile; With water; sodium hydroxide; In ethanol; at 120 ℃;

With hydrogenchloride; In ethanol; water; pH=< 6;

Reference yield:

: 5782-69-4
6-isopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1416146-09-2
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

2.1: triethylamine / dmap / dichloromethane / 2.5 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / 0.75 h / 175 °C / Microwave irradiation

4.1: triethylamine / tetrahydrofuran / 4 h / 0 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

6.1: sodium hydroxide; water / ethanol / 120 °C

6.2: pH < 6

With N-Bromosuccinimide; water; potassium carbonate; triethylamine; sodium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1416146-12-7
5-bromo-6-isopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1416146-09-2
(R)-5-(4-fluorophenyl)-6-isopropyl-2-(4-(4-methoxybenzyl)-3-methylpiperazin-1-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dmap / dichloromethane / 2.5 h / 0 - 20 °C

2.1: triethylamine / acetonitrile / 0.75 h / 175 °C / Microwave irradiation

3.1: triethylamine / tetrahydrofuran / 4 h / 0 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

5.1: sodium hydroxide; water / ethanol / 120 °C

5.2: pH < 6

With water; potassium carbonate; triethylamine; sodium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;