(adamant-1-yl)methyl 4-hydroxyphenylacetate

Base Information

• Chemical Name: (adamant-1-yl)methyl 4-hydroxyphenylacetate
• CAS No.: 114653-05-3
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.398
• Mol file: 114653-05-3.mol

Synonyms:(adamant-1-yl)methyl 4-hydroxyphenylacetate

Chemical Property of (adamant-1-yl)methyl 4-hydroxyphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (adamant-1-yl)methyl 4-hydroxyphenylacetate

There total 7 articles about (adamant-1-yl)methyl 4-hydroxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxyphenylacetate (156-38-7) + 1-adamantanemethanol (770-71-8) → (adamant-1-yl)methyl 4-hydroxyphenylacetate (114653-05-3)

Guidance literature:

With toluene-4-sulfonic acid; In benzene;

Reference yield:

[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid adamantan-1-ylmethyl ester (114652-99-2) → (adamant-1-yl)methyl 4-hydroxyphenylacetate (114653-05-3)

Guidance literature:

With oxalic acid; In methanol; for 1h; Heating;

DOI:10.1021/jm00403a028

Reference yield:

4-hydroxyphenylacetate (156-38-7) → (adamant-1-yl)methyl 4-hydroxyphenylacetate (114653-05-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 93.5 percent / conc. H₂SO₄ / 1 h / Heating

2: 99 percent / HCl gas / tetrahydrofuran; ethyl acetate / 29 h / Ambient temperature

3: 87 percent / aq. NaOH / methanol / 18 h / Ambient temperature

4: p-toluenesulfonic acid / pyridine / 16 h / Ambient temperature

5: aq. oxalic acid / methanol / 1 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; oxalic acid; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; ethyl acetate;

DOI:10.1021/jm00403a028

upstream raw materials:

[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid adamantan-1-ylmethyl ester

4-hydroxyphenylacetate

1-adamantanemethanol

(4-hydroxy-phenyl)-acetic acid ethyl ester

Downstream raw materials:

(4-Oxiranylmethoxy-phenyl)-acetic acid adamantan-1-ylmethyl ester

[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-acetic acid adamantan-1-ylmethyl ester