tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate

Base Information

• Chemical Name: tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate
• CAS No.: 1189566-01-5
• Molecular Formula: C₁₇H₃₀O₇P₂
• Molecular Weight: 408.369
• Mol file: 1189566-01-5.mol

Synonyms:tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate

Chemical Property of tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate

There total 4 articles about tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-bis(bromomethyl)-5-hydroxymethylbenzene (200809-09-2) + triethyl phosphite (122-52-1) → tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate (1189566-01-5)

Guidance literature:

at 140 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3cc43161d

Reference yield: 96.0%

tetraethyl {5-[(tert-butyldiphenylsilyloxy)methyl]-1,3-phenylene}bis(methylene)diphosphonate (1189566-00-4) → tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate (1189566-01-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200900589

Reference yield:

methyl 3,5-bis(bromomethyl)benzoate (29333-41-3) → tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate (1189566-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 3 h / 0 °C / Inert atmosphere

2: 2 h / 140 °C / Inert atmosphere

With diisobutylaluminium hydride; In toluene;

DOI:10.1039/c3cc43161d

upstream raw materials:

tetraethyl {5-[(tert-butyldiphenylsilyloxy)methyl]-1,3-phenylene}bis(methylene)diphosphonate

methyl 3,5-bis(bromomethyl)benzoate

1,3-bis(bromomethyl)-5-hydroxymethylbenzene

triethyl phosphite

Downstream raw materials:

Tetraethyl 5-formyl-1,3-phenylenebis(methylenephosphonate)

C₁₇H₂₉ClO₆P₂

C₁₇H₂₉N₃O₆P₂

C₄₀H₆₈N₆O₂₀P₂