29333-41-3

Usage

Uses

Used in Organic Synthesis:
Methyl 3,5-bis(bromomethyl)benzoate is utilized as a key building block in the preparation of various benzene-containing compounds. Its reactivity and structural properties make it suitable for the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, methyl 3,5-bis(bromomethyl)benzoate is employed as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Methyl 3,5-bis(bromomethyl)benzoate also finds application in the agrochemical industry, where it is used as a chemical intermediate in the production of agrochemicals. Its properties enable the synthesis of compounds with potential pesticidal or herbicidal activities.
Used in Fragrance and Flavor Industry:
In the fragrance and flavor industry, methyl 3,5-bis(bromomethyl)benzoate is used as a chemical intermediate for the production of fragrances and flavor compounds. Its strong, sweet odor and reactivity make it a valuable component in creating various scent and taste profiles.
Overall, the diverse applications of methyl 3,5-bis(bromomethyl)benzoate across different industries highlight its importance as a versatile chemical intermediate and building block in organic synthesis.

Upstream product

• 25081-39-4 methyl 3,5-dimethylbenzoate 
• 499-06-9 3,5-dimethylbenzoic acid 
• 193953-02-5 3,5-bis(hydroxylmethyl)benzoic acid methyl ester 
• 18263-95-1 3,5-dicarboxylic acid-1-benzoic acid methyl ester 
• 2672-58-4 1,3,5-tris-(methoxycarbonyl)benzene 
• 859238-49-6 (3-hydroxymethyl-5-iodo-phenyl)-methanol 
• 1111715-86-6 (((5-iodo-1,3-phenylene)bis(methylene))bis(oxy))bis(tert-butyldimethylsilane) 
• 6613-44-1 3,5-dimethylbenzoyl chloride 

Downstream Products

• 71169-69-2 3,5-bis(sulfanylmethyl)benzoic acid 
• 145665-38-9 methyl 3,5-bis(azidomethyl)benzoate 
• 185963-31-9 methyl 3,5-bis((N-formylformamido)methyl)benzoate 
• 224961-41-5 3,5-bis-{3,5-bis-[bis-(2-methoxy-ethyl)-carbamoyl]-phenoxymethyl}-benzoic acid methyl ester 
• 358365-78-3 3,10-bis-(2-nitro-benzenesulfonyl)-3,6,10-triaza-bicyclo[10.3.1]hexadeca-1⁽¹⁶⁾,12,14-triene-6,14-dicarboxylic acid 6-tert-butyl ester 14-methyl ester 
• 29232-73-3 3,5-bis-cyanomethyl-benzoic acid methyl ester 
• 134179-29-6 methyl-3-bromomethyl-5-bis(Boc)aminomethyl-benzoate 
• 1449424-75-2 C₉H₁₂O₈P₂*C₃H₆O 
• 1202493-19-3 methyl 3,5-bis[(diethoxyphosphoryl)methyl]benzoate 
• 223449-25-0 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester 
• 223449-19-2 5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester 

Relevant academic research and scientific papers

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

A DNA-encoded chemical library (DECL) with 1.2 million compounds was synthesized by combinatorial reaction of seven central scaffolds with two sets of 343×492 building blocks. Library screening by affinity capture revealed that for some target proteins, the chemical nature of building blocks dominated the selection results, whereas for other proteins, the central scaffold also crucially contributed to ligand affinity. Molecules based on a 3,5-bis(aminomethyl)benzoic acid core structure were found to bind human serum albumin with a Kd value of 6 nm, while compounds with the same substituents on an equidistant but flexible l-lysine scaffold showed 140-fold lower affinity. A 18 nm tankyrase-1 binder featured l-lysine as linking moiety, while molecules based on d-Lysine or (2S,4S)-amino-l-proline showed no detectable binding to the target. This work suggests that central scaffolds which predispose the orientation of chemical building blocks toward the protein target may enhance the screening productivity of encoded libraries.

Non-Peptidic Cell-Penetrating Motifs for Mitochondrion-Specific Cargo Delivery

Mitochondrial dysfunction is linked to a variety of human illnesses, but selective delivery of therapeutics into the mitochondrion is challenging. Now a family of amphipathic cell-penetrating motifs (CPMs) is presented, consisting of four guanidinium groups and one or two aromatic hydrophobic groups (naphthalene) assembled through a central scaffold (a benzene ring). The CPMs and CPM-cargo conjugates efficiently enter the interior of cultured mammalian cells and are specifically localized into the mitochondrial matrix, as revealed by high-resolution confocal microscopy. With a membrane-impermeable peptide as cargo, the CPMs exhibited ≥170-fold higher delivery efficiency than previous mitochondrial delivery vehicles. Conjugation of a small-molecule inhibitor of heat shock protein 90 to a CPM resulted in accumulation of the inhibitor inside the mitochondrial matrix with greatly enhanced anticancer activity. The CPMs showed minimal effect on the viability or the mitochondrial membrane potential of mammalian cells.

Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium

The development of biocompatible coatings is an ongoing issue. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix improves cell adhesion of osteoblasts in vitro and results in improved and earlier osseous integration o

CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES

The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a

GLUCOSE SENSITIVE INSULIN DERIVATIVES

The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention

Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells

In this study, we describe the synthesis and biological evaluation of a set of bis-3-chloropiperidines (B?CePs) containing rigid aromatic linker structures. A modification of the synthetic strategy also enabled the synthesis of a pilot tris-3-chloropiperidine (Tri-CeP) bearing three reactive meta-chloropiperidine moieties on the aromatic scaffold. A structure–reactivity relationship analysis of B?CePs suggests that the arrangement of the reactive units affects the DNA alkylating activity, while also revealing correlations between the electron density of the aromatic system and the reactivity with biologically relevant nucleophiles, both on isolated DNA and in cancer cells. Interestingly, all aromatic 3-chloropiperidines exhibited a marked cytotoxicity and tropism for 2D and 3D cultures of pancreatic cancer cells. Therefore, the new aromatic 3-chloropiperidines appear to be promising contenders for further development of mustard-based anticancer agents aimed at pancreatic cancers.

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF AS ANTITUMOUR AGENTS

A compound with the formula I: (I) and salts and solvates thereof, wherein: R" is a group of formula II: (II) where each of n and m are independently selected from 1, 2 and 3.

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

NON-PEPTIDIC CELL-PENETRATING MOTIFS

Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria.

DI-SULFIDE CONTAINING CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF

Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bic