29333-41-3

Basic information

• Product Name: methyl 3,5-bis(bromomethyl)benzoate
• Synonyms: methyl 3,5-bis(bromomethyl)benzoate
• CAS NO: 29333-41-3
• Molecular Formula: C₁₀H₁₀Br₂O₂
• Molecular Weight: 321.9932
• Mol File: 29333-41-3.mol
• Article Data: 38

Chemical Properties

• Melting Point: 91-93 °C
• Boiling Point: 375.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.728±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: methyl 3,5-bis(bromomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,5-bis(bromomethyl)benzoate(29333-41-3)
• EPA Substance Registry System: methyl 3,5-bis(bromomethyl)benzoate(29333-41-3)

Safety Data

• Hazardous Substances Data: 29333-41-3(Hazardous Substances Data)

Usage

General Description

Methyl 3,5-bis(bromomethyl)benzoate is a chemical compound with the molecular formula C10H8Br2O2. It is an ester formed from the reaction of methyl 3,5-dihydroxybenzoate with bromomethane. methyl 3,5-bis(bromomethyl)benzoate is widely used in organic synthesis for the preparation of various benzene-containing compounds. It is a colorless, crystalline solid with a strong, sweet odor. Due to its bromine substituents, it is highly reactive and is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a chemical intermediate in the production of fragrances and flavor compounds.

Upstream product

• 18263-95-1 3,5-dicarboxylic acid-1-benzoic acid methyl ester 
• 2672-58-4 1,3,5-tris-(methoxycarbonyl)benzene 
• 193953-02-5 3,5-bis(hydroxylmethyl)benzoic acid methyl ester 
• 499-06-9 3,5-dimethylbenzoic acid 
• 25081-39-4 methyl 3,5-dimethylbenzoate 
• 6613-44-1 3,5-dimethylbenzoyl chloride 
• 859238-49-6 (3-hydroxymethyl-5-iodo-phenyl)-methanol 
• 1111715-86-6 (((5-iodo-1,3-phenylene)bis(methylene))bis(oxy))bis(tert-butyldimethylsilane) 

Downstream Products

• 1449424-75-2 C₉H₁₂O₈P₂*C₃H₆O 
• 1202493-19-3 methyl 3,5-bis[(diethoxyphosphoryl)methyl]benzoate 
• 223449-25-0 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester 
• 223449-19-2 5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester 
• 71169-69-2 3,5-bis(sulfanylmethyl)benzoic acid 
• 1046342-51-1 methyl 3,5-bis[(acetylsulfanyl)methyl]benzoate 
• 29232-73-3 3,5-bis-cyanomethyl-benzoic acid methyl ester 
• 1350629-68-3 5-bis[[bis(2-pyridylmethyl)amino]methyl]benzoic acid triethylamine salt 

Relevant articles and documents

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

A DNA-encoded chemical library (DECL) with 1.2 million compounds was synthesized by combinatorial reaction of seven central scaffolds with two sets of 343×492 building blocks. Library screening by affinity capture revealed that for some target proteins, the chemical nature of building blocks dominated the selection results, whereas for other proteins, the central scaffold also crucially contributed to ligand affinity. Molecules based on a 3,5-bis(aminomethyl)benzoic acid core structure were found to bind human serum albumin with a Kd value of 6 nm, while compounds with the same substituents on an equidistant but flexible l-lysine scaffold showed 140-fold lower affinity. A 18 nm tankyrase-1 binder featured l-lysine as linking moiety, while molecules based on d-Lysine or (2S,4S)-amino-l-proline showed no detectable binding to the target. This work suggests that central scaffolds which predispose the orientation of chemical building blocks toward the protein target may enhance the screening productivity of encoded libraries.

Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium

The development of biocompatible coatings is an ongoing issue. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix improves cell adhesion of osteoblasts in vitro and results in improved and earlier osseous integration o

GLUCOSE SENSITIVE INSULIN DERIVATIVES

The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention

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