(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Base Information

Chemical Name:(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid
CAS No.:1616119-02-8
Molecular Formula:C₁₉H₁₈N₂O₄
Molecular Weight:338.363
Hs Code.:

Synonyms:(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

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Chemical Property of (E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

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Technology Process of (E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

There total 8 articles about (E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1616119-49-3
(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

: 1616119-02-8
(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Guidance literature:: With sodium hydroxide; In isopropyl alcohol; at 62 - 65 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 14510-06-6
2-formyl oxine

: 1616119-02-8
(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

2: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

4: sodium hydroxide / isopropyl alcohol / 0.67 h / 62 - 65 °C

With 1H-imidazole; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 1616119-20-0
ethyl 2-(2-bromoacetamido)cyclohex-1-enecarboxylate

: 1616119-02-8
(E)-2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 3 h / Reflux

2: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

4: sodium hydroxide / isopropyl alcohol / 0.67 h / 62 - 65 °C

With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; isopropyl alcohol; benzene; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011