(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Base Information

Chemical Name:(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate
CAS No.:1616119-49-3
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Suppliers and Price of (E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

There total 7 articles about (E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1616119-47-1
(E)-ethyl 2-(3-(8-((tert-butyldimethylsilyl)oxy)quinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

: 1616119-49-3
(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 10 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 14510-06-6
2-formyl oxine

: 1616119-49-3
(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

2: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

With 1H-imidazole; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 1070896-53-5
2-quinolinecarboxaldehyde, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]

: 1616119-49-3
(E)-ethyl 2-(3-(8-hydroxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; 1: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011