3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Base Information

Chemical Name:3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole
CAS No.:108894-42-4
Molecular Formula:C₂₆H₃₀N₂O₆S
Molecular Weight:498.6
Hs Code.:

Synonyms:3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

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Chemical Property of 3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

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Technology Process of 3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

There total 4 articles about 3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

: 115-18-4
2-methyl-3-buten-2-ol

: 108868-40-2
3-(2-acetamido-2-carbomethoxyethyl)-4-bromo-1-tosylindole

: 108894-42-4
3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; at 100 ℃; for 5h;
DOI:10.1021/ja00248a032

Reference yield:

: 35356-70-8
Methyl 2-acetamidoacrylate

: 108894-42-4
3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / triethylamine / 5percent palladium(II)acetate / acetonitrile / 5 h / Heating

2: hydrogen / Wilkinson's catalyst / methanol / 21.5 h / 3361.5 Torr / Ambient temperature

3: 91.9 percent / Et₃N, tri-o-tolylphosphine / Pd(OAc)2 / 5 h / 100 °C

With hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; Wilkinson's catalyst; palladium diacetate; In methanol; acetonitrile;
DOI:10.1021/ja00248a032

Reference yield:

: 108868-37-7
4-bromo-3-(2-acetamido-2-carbomethoxyethen-1-yl)-1-tosylindole

: 108894-42-4
3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Wilkinson's catalyst / methanol / 21.5 h / 3361.5 Torr / Ambient temperature

2: 91.9 percent / Et₃N, tri-o-tolylphosphine / Pd(OAc)2 / 5 h / 100 °C

With hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; Wilkinson's catalyst; In methanol;
DOI:10.1021/ja00248a032