N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

Base Information

Chemical Name:N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide
CAS No.:330796-30-0
Molecular Formula:C₂₄H₁₉F₄N₃O₃S
Molecular Weight:505.493
Hs Code.:

Synonyms:N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

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Chemical Property of N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

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Technology Process of N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

There total 5 articles about N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 330796-26-4
3-(4-fluoro-phenyl)-2-(1-methylamino-ethyl)-3H-quinazolin-4-one

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 330796-30-0
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

Guidance literature:: 3-(4-fluoro-phenyl)-2-(1-methylamino-ethyl)-3H-quinazolin-4-one; 3-(Trifluoromethyl)benzenesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

With dmap; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 329190-49-0
2-(1-bromo-ethyl)-3-(4-fluoro-phenyl)-3H-quinazolin-4-one

: 330796-30-0
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 1 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 330796-30-0
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.5 h / 140 °C

2.1: chloroform / Reflux

3.1: sodium acetate; acetic acid; bromine / 5 h / 40 °C / Inert atmosphere

4.1: ethanol / 1 h / 40 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

With bromine; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; chloroform;