330796-26-4

Upstream product

• 329190-48-9 2-Ethyl-3-(4-fluorophenyl)-3H-quinazolin-4-one 
• 2916-09-8 2-ethyl-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 329190-49-0 2-(1-bromo-ethyl)-3-(4-fluoro-phenyl)-3H-quinazolin-4-one 
• 74-89-5 methylamine 

Downstream Products

• 330796-29-7 N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide 
• 330796-30-0 N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzenesulfonamide 
• 330796-28-6 2-{1-[N-(2-methoxy-5-trifluoromethylphenylcarbamoyl)-N-methylamino]ethyl}-3-(4'-fluorophenyl)quinazolin-4-one 
• 330796-44-6 1-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1-methyl-3-(3-trifluoromethanesulfonylphenyl)urea 
• 330796-46-8 1-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-3-(3-trifluoromethyl-4-nitrophenyl)-1-methylurea 
• 330796-45-7 1-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-3-[3-trifluoromethyl-4-(4-methyl)piperazin-1-ylphenyl]-1-methylurea 

Relevant academic research and scientific papers

Mediators of hedgehog signaling pathways, compositions and uses related thereto

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

Potent inhibitors of the Hedgehog signaling pathway

A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.