(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol

Base Information

• Chemical Name: (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol
• CAS No.: 461641-18-9
• Molecular Formula: C₂₄H₃₃NO₂
• Molecular Weight: 367.532

Synonyms:(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol

Chemical Property of (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol

Chemical Property:

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Technology Process of (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol

There total 3 articles about (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2,6,6-trimethyl-cyclohex-1-enyl)-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid methyl ester (461640-94-8) → (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol (461641-18-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.0833333h;

DOI:10.1021/jo049381f

Reference yield:

methyl (E,E)-4-oxo-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoate (128293-12-9) → (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol (461641-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CHCl₃ / 1 h / 20 °C

2: 100 percent / LiAlH₄ / diethyl ether / 0.08 h / 20 °C

With lithium aluminium tetrahydride; In diethyl ether; chloroform;

DOI:10.1021/jo049381f

Reference yield:

(1S,2R)-1-amino-2-indanol (7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8) → (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol (461641-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CHCl₃ / 1 h / 20 °C

2: 100 percent / LiAlH₄ / diethyl ether / 0.08 h / 20 °C

With lithium aluminium tetrahydride; In diethyl ether; chloroform;

DOI:10.1021/jo049381f

upstream raw materials:

4-(2,6,6-trimethyl-cyclohex-1-enyl)-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid methyl ester

methyl (E,E)-4-oxo-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoate

(1S,2R)-1-amino-2-indanol

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