3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide
• CAS No.: 955084-69-2
• Molecular Formula: C₁₆H₁₃Cl₂N₅O
• Molecular Weight: 362.218

Synonyms:3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide

Chemical Property of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide

There total 3 articles about 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylate → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide (955084-69-2)

Guidance literature:

With hydrazine hydrate; In methanol; Heating;

DOI:10.1016/j.bmc.2007.08.021

Reference yield:

2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide (955084-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 0.5 h / 120 °C / Microwave irradiation

2: hydrazine hydrate / methanol / 65 °C

With potassium carbonate; hydrazine hydrate; In methanol; acetonitrile;

DOI:10.1016/j.bmc.2012.01.032

Reference yield:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester (938182-43-5,595610-40-5) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide (955084-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 0.5 h / 120 °C / Microwave irradiation

2: hydrazine hydrate / methanol / 65 °C

With potassium carbonate; hydrazine hydrate; In methanol; acetonitrile;

DOI:10.1016/j.bmc.2012.01.032

upstream raw materials:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

2-chloro-5-(chloromethyl)pyridine

Downstream raw materials:

C₂₁H₁₅Cl₂N₅O₂

C₂₄H₁₇Cl₂N₅O₃

C₂₄H₁₉Cl₂N₅O₂

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

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