3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

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Chemical Name:3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide
CAS No.:1009091-14-8
Molecular Formula:C₂₃H₁₇Cl₂N₅O₂
Molecular Weight:466.326
Hs Code.:

Synonyms:3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

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Chemical Property of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

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Technology Process of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

There total 4 articles about 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 955084-69-2
3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbohydrazide

: 90-02-8
salicylaldehyde

: 1009091-14-8
3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

Guidance literature:: In ethanol; Heating;
DOI:10.1016/j.ejmech.2008.01.021

Reference yield:

: ethyl 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylate

: 1009091-14-8
3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 65 °C

2: ethanol / 5 h / 30 °C

With hydrazine hydrate; In methanol; ethanol;
DOI:10.1016/j.bmc.2012.01.032

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 1009091-14-8
3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 0.5 h / 120 °C / Microwave irradiation

2: hydrazine hydrate / methanol / 65 °C

3: ethanol / 5 h / 30 °C

With potassium carbonate; hydrazine hydrate; In methanol; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.01.032