(S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride

Base Information

• Chemical Name: (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride
• CAS No.: 1375278-24-2
• Molecular Formula: C₁₇H₁₈N₂O₃*ClH
• Molecular Weight: 334.802
• Mol file: 1375278-24-2.mol

Synonyms:(S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride

Chemical Property of (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride

There total 4 articles about (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-tert-butyl(1-(benzo[d][1,3]dioxol-5-yl(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (1375278-23-1) → (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride (1375278-24-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

Reference yield:

benzo[1,3]dioxolo-5-ylamine (14268-66-7) → (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride (1375278-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 24 h / 20 °C

1.2: 3 h / 40 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / methanol / 1 h / 20 °C

With hydrogenchloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

N-methyl-3,4-(methylenedioxy)aniline (34060-22-5) → (S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide hydrochloride (1375278-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / methanol / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

benzo[1,3]dioxolo-5-ylamine

N-methyl-3,4-(methylenedioxy)aniline

(S)-tert-butyl(1-(benzo[d][1,3]dioxol-5-yl(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Downstream raw materials:

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2,4,7-trimethyl-1H-indol-3-yl)acetamido)-N-methyl-3-phenylpropanamide

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-bromoacetamido)-N-methyl-3-phenylpropanamide

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Refernces

• 1、 -. "ANTIVIRAL COMPOUNDS". . . Retrieved 2013/03/26.