{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

Base Information

Chemical Name:{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester
CAS No.:610298-73-2
Molecular Formula:C₂₉H₂₇FN₂O₃
Molecular Weight:470.543
Hs Code.:

Synonyms:{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

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Chemical Property of {2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

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Technology Process of {2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

There total 4 articles about {2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026870-16-5
Carbonic acid 4-fluoro-2-(5-{2-[2-(methoxycarbonyl-methyl-amino)-phenyl]-acetyl}-2,2,4-trimethyl-1,2-dihydro-quinolin-6-yl)-phenyl ester methyl ester

: 610298-73-2
{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

Guidance literature:: Carbonic acid 4-fluoro-2-(5-{2-[2-(methoxycarbonyl-methyl-amino)-phenyl]-acetyl}-2,2,4-trimethyl-1,2-dihydro-quinolin-6-yl)-phenyl ester methyl ester; With sodium carbonate; In 1,4-dioxane; methanol; at 80 ℃; for 2h;

With toluene-4-sulfonic acid; In dichloromethane; for 2h;
DOI:10.1021/jm020477g

Reference yield:

: 611-21-2
N,2-dimethylaniline

: 610298-73-2
{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; CO₂ (gas) / tetrahydrofuran; hexane / -78 - -15 °C

1.2: n-BuLi / tetrahydrofuran / -78 - 15 °C

1.3: 0.10 g / tetrahydrofuran; hexane / -78 - -40 °C

2.1: pyridine / CH₂Cl₂ / 0.17 h

3.1: Na₂CO₃ / methanol; dioxane / 2 h / 80 °C

3.2: 40 mg / TsOH / CH₂Cl₂ / 2 h

With pyridine; n-butyllithium; carbon dioxide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jm020477g

Reference yield:

: 179895-41-1
9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-5-one

: 610298-73-2
{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; CO₂ (gas) / tetrahydrofuran; hexane / -78 - -15 °C

1.2: n-BuLi / tetrahydrofuran / -78 - 15 °C

1.3: 0.10 g / tetrahydrofuran; hexane / -78 - -40 °C

2.1: pyridine / CH₂Cl₂ / 0.17 h

3.1: Na₂CO₃ / methanol; dioxane / 2 h / 80 °C

3.2: 40 mg / TsOH / CH₂Cl₂ / 2 h

With pyridine; n-butyllithium; carbon dioxide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jm020477g