2-benzyl-2-phenylmalononitrile

Base Information

• Chemical Name: 2-benzyl-2-phenylmalononitrile
• CAS No.: 861356-28-7
• Molecular Formula: C₁₆H₁₂N₂
• Molecular Weight: 232.285
• Mol file: 861356-28-7.mol

Synonyms:2-benzyl-2-phenylmalononitrile

Chemical Property of 2-benzyl-2-phenylmalononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-2-phenylmalononitrile

There total 10 articles about 2-benzyl-2-phenylmalononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-dimethylmalononitrile (7321-55-3) + benzyl bromide (100-39-0) + phenylacetonitrile (140-29-4) → 2-benzyl-2-phenylmalononitrile (861356-28-7)

Guidance literature:

phenylacetonitrile; With methylmagnesium bromide; lithium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h; Inert atmosphere;

2,2-dimethylmalononitrile; In tetrahydrofuran; diethyl ether; at 80 ℃; for 6h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2019.05.004

Reference yield: 89.0%

Benzylmalononitrile (1867-37-4) + Diphenyliodonium triflate (66003-76-7) → 2-benzyl-2-phenylmalononitrile (861356-28-7)

Guidance literature:

Benzylmalononitrile; With potassium tert-butylate; In dichloromethane; at 0 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

Diphenyliodonium triflate; In dichloromethane; at 0 - 20 ℃; for 1.08333h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0036-1589061

Reference yield: 88.0%

2-phenylmalononitrile (3041-40-5) + benzyl bromide (100-39-0) → 2-benzyl-2-phenylmalononitrile (861356-28-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201908372

upstream raw materials:

2-Cyano-2-phenylacetic acid amide

phenylacetonitrile

ethyl phenylcyanoacetate

benzyl chloride

Downstream raw materials:

2,3-diphenylpropionitrile

Refernces

• 1、 Weweler, Jens,Younas, Sara L.,Streuff, Jan. "Titanium(III)-Catalyzed Reductive Decyanation of Geminal Dinitriles by a Non-Free-Radical Mechanism". supporting information. p. 17700 - 17703. Retrieved 2019/11/13.
• 2、 -. "MALONONITRILE COMPOUNDS FOR CONTROLLING ANIMAL PESTS". Page/Page column 184. . Retrieved 2014/05/24.