2,4,6-trimethoxy-3-methylbenzenemethanol

Base Information

• Chemical Name: 2,4,6-trimethoxy-3-methylbenzenemethanol
• CAS No.: 171670-29-4
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.246
• Mol file: 171670-29-4.mol

Synonyms:2,4,6-trimethoxy-3-methylbenzenemethanol

Chemical Property of 2,4,6-trimethoxy-3-methylbenzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-trimethoxy-3-methylbenzenemethanol

There total 4 articles about 2,4,6-trimethoxy-3-methylbenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2,4,6-trimethoxy-3-methylbenzoate (97944-49-5) → 2,4,6-trimethoxy-3-methylbenzenemethanol (171670-29-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1016/0022-328X(95)05688-L

Reference yield: 92.0%

2,4,6-trimethoxy-3-methylbenzaldehyde (81574-58-5) → 2,4,6-trimethoxy-3-methylbenzenemethanol (171670-29-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.03.049

Reference yield:

2,4,6-trimethoxytoluene (14107-97-2) → 2,4,6-trimethoxy-3-methylbenzenemethanol (171670-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.tetlet.2016.03.049

upstream raw materials:

methyl 2,4,6-trimethoxy-3-methylbenzoate

2,4,6-trimethoxybenzaldehyde

2,4,6-trimethoxytoluene

2,4,6-trimethoxy-3-methylbenzaldehyde

Downstream raw materials:

2,4,6-trimethoxy-3-methyl-1-chloromethylbenzene

Refernces

• 1、 Ancker, Tania R. van den,Harvey, Steven,Raston, Colin L.. "Polymer supported magnesium anthracene: application in the synthesis of benzylic Grignard reagents". . p. 35 - 46. Retrieved 2007/10/02.