14107-97-2

Basic information

• Product Name: 2,4,6-TRIMETHOXYTOLUENE
• Synonyms: Benzene, 1,3,5-trimethoxy-2-methyl-;Toluene, 2,4,6-trimethoxy-;1,3,5-Trimethoxy-4-methylbenzene;1-Methyl-2,4,6-trimethoxybenzene;2-Methyl-1,3,5-trimethoxybenzene;Einecs 237-962-8;2,4,6-TRIMETHOXYTOLUENE;1,3,5-trimethoxy-2-methyl-benzen
• CAS NO: 14107-97-2
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.22
• EINECS: 237-962-8
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives
• Mol File: 14107-97-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 27-28°C
• Boiling Point: 100-105°C 1mm
• Flash Point: 100-105°C/1mm
• Appearance: /
• Density: 1.025g/cm³
• Vapor Pressure: 0.0032mmHg at 25°C
• Refractive Index: 1.5310
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Sparingly)
• BRN: 2048952
• CAS DataBase Reference: 2,4,6-TRIMETHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHOXYTOLUENE(14107-97-2)
• EPA Substance Registry System: 2,4,6-TRIMETHOXYTOLUENE(14107-97-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 14107-97-2(Hazardous Substances Data)

Usage

Description

2,4,6-TRIMETHOXYTOLUENE, also known as TMT, is a chemical compound characterized by the molecular formula C9H12O3. It is a colorless to pale yellow liquid with a distinctive floral scent. TMT is primarily utilized as an intermediate in the synthesis of fragrances and perfumes, contributing to the creation of various aromatic compounds. Additionally, it serves as a solvent in the production of resins, adhesives, and coatings, highlighting its versatility in industrial applications. Despite its low acute toxicity, prolonged exposure to high concentrations of TMT may result in skin, eye, and respiratory irritation, necessitating proper handling and safety measures.

Uses

Used in the Fragrance and Perfumery Industry:
2,4,6-TRIMETHOXYTOLUENE is used as an intermediate in the synthesis of fragrances and perfumes for its ability to contribute to the creation of a wide range of aromatic compounds. Its floral scent adds depth and complexity to various fragrance formulations, enhancing the overall sensory experience.
Used in the Production of Resins, Adhesives, and Coatings:
2,4,6-TRIMETHOXYTOLUENE is used as a solvent in the manufacturing process of resins, adhesives, and coatings. Its solvent properties facilitate the blending and application of these materials, ensuring optimal performance and adherence to various surfaces. The use of TMT in these applications underscores its importance in the production of a diverse array of industrial products.

InChI:InChI=1/C10H14O3/c1-7-9(12-3)5-8(11-2)6-10(7)13-4/h5-6H,1-4H3

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 616-38-6 carbonic acid dimethyl ester 
• 621-23-8 1,2,3-trimethoxybenzene 
• 124-38-9 carbon dioxide 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 141-78-6 ethyl acetate 
• 39828-36-9 2-hydroxy-4,6-dimethoxytoluene 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 
• 97944-49-5 methyl 2,4,6-trimethoxy-3-methylbenzoate 
• 61040-78-6 2,4,6-trimethoxybenzyl alcohol 

Downstream Products

• 916917-28-7 (+/-)-8-Methylnaringenin 
• 916917-16-3 8-methyl-5,7,4'-tris(methoxymethoxy)flavanone 
• 2657-28-5 2,4,6-trihydroxy-3-methyl-acetophenon 
• 106929-57-1 3-methyl-2-hydroxy-4,6-bis(methoxymethoxy)acetophenone 
• 92301-90-1 2-methyl-1-(2,4,6-trimethoxy-3-methylphenyl)propan-1-one 
• 39828-36-9 2-hydroxy-4,6-dimethoxytoluene 
• 22080-97-3 3,5-dimethoxy-4-methylphenol 
• 21722-31-6 1-(2-hydroxy-4,6-dimethoxy-3,5-dimethylphenyl)ethanone 
• 1521-61-5 1,3,5-trimethoxy-2,4-dimethyl benzene 

Relevant articles and documents

Efficient synthesis of rottlerin and its two subunits

Rottlerin, a natural product isolated from Mallotus philippensis, is associated with a range of biological activities. Its chemical structure is featured by two different substituted phloroglucinol units linked by a methylene group. In this study, we accomplished a total synthesis of rottlerin using phenol-aldehyde condensation as the key reaction. By our method, gram-scale preparation of the two structural subunits was achieved, and rottlerin was obtained in a longest eight linear step with 20% overall yield. Our study provides a practical solution for obtaining the sample of rottlerin in an efficient way.

Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies

Phloroglucinol compounds isolated from Dryopteris fragrans (L.) Schott showed a variety of biological activities, such as anticancer and anti-inflammatory. In this study, we have made a number of modifications around the scaffold of phloroglucinol and synthesized phloroglucinol derivatives A1–A9, B1–B9, and C1–C3. We synthesized these compounds and investigated their effect on four human cancer cell lines (A-549, MCF-7, Hela, HepG2 cell lines) via MTT assay in vitro. The results revealed that all compounds exhibited certain antiproliferative activities on cancer cell lines and excellent inhibitory effects on MCF-7, in which compound C2 was the best with the IC50 value of 18.49 μM, exceeding that of 5-fluorouracil. Moreover, the cell apoptosis test showed that compound C2 induced apoptosis in a concentration-dependent manner. Furthermore, the results of molecular docking analysis explained the probable interaction between the active compounds and active sites of target protein 4I22 and 1OG5. [Figure not available: see fulltext.]

Dryopteris fragrans phloroglucinol compound flavaspidic acid BB and antibacterial application thereof

The invention relates to the technical field of medicine and discloses an antibacterial application of a Dryopteris fragrans phloroglucinol compound flavaspidic acid BB. The invention provides the flavaspidic acid BB obtained by the chemical synthesis method. The flavaspidic acid BB has good antibacterial effects, effectively fills in the application deficiency of the antibacterial natural compound and provides an effective antibacterial solution for drug-resistant bacteria. The experimental results show that the compound has a strong antibacterial effect and good curative effects especially on drug-resistant bacteria.